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A0401

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

Synonym(s):

ACTH4-10

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About This Item

Empirical Formula (Hill Notation):
C44H59N13O10S
CAS Number:
4037-01-8
Molecular Weight:
962.09
MDL number:
MFCD00167482
UNSPSC Code:
12352202
PubChem Substance ID:
24890423
NACRES:
NA.26

product name

Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)

Assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189
P47866

storage temp.

−20°C

SMILES string

CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O

InChI

1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

InChI key

HAAUASBAIUJHAN-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)
rat ... Crhr2(64680)

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.
Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Quality

Lacks adrenocorticotropic activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Manfred Hallschmid et al.
The Journal of clinical endocrinology and metabolism, 91(2), 522-525 (2005-12-01)
By enhancing energy expenditure and suppressing appetite, melanocortin peptides derived from proopiomelanocortin play a primary role in the hypothalamic regulation of body weight. In a recent study in normal-weight adults, the 6-wk intranasal administration of the MSH/ACTH(4-10) core fragment of
Neonatal administration of ACTH4-10 and its analog Semax to young laboratory mice modulates the number of catecholaminergic neurons in adult animal diencephalon.
O S Boyarshinova et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 396, 181-183 (2004-09-10)
Sniffing neuropeptides: a transnasal approach to the human brain.
Jan Born et al.
Nature neuroscience, 5(6), 514-516 (2002-05-07)
Kun Wang et al.
International immunopharmacology, 87, 106769-106769 (2020-07-19)
In the present study, we aimed to assess whether adrenocorticotropic hormone (ACTH) could protect the podocytes from adriamycin (ADR)-induced injury by stimulating B lymphocytes to secrete the associated cytokines. Proliferation assay was used to assess the proliferation and activity of
Bela Juhasz et al.
Antioxidants & redox signaling, 9(11), 1851-1861 (2007-08-25)
The aim of our study was to investigate the contribution of the adrenocorticotropic hormone fragment, ACTH (4-10), on the recovery of postischemic cardiac function. Effects of ACTH (4-10) on caspase-3 activity, cardiomyocyte and endothelial apoptosis, and HO-1 protein expression were
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