Tetracycline is soluble in methanol, giving a clear solution at up to 30 mg/ml. It is practically insoluble in chloroform and ether, very slightly soluble in water, slightly soluble in alcohol, very soluble in dilute hydrochloric acid and alkali hydroxide solutions.
87128
Tetracycline
98.0-102.0% (HPLC)
Synonym(s):
Tetracycline HCL, Tetracycline Monohydrochloride
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25 G
€84.30
100 G
€290.00
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25 G
€84.30
100 G
€290.00
About This Item
Empirical Formula (Hill Notation):
C22H24N2O8 · xH2O
CAS Number:
Molecular Weight:
444.43 (anhydrous basis)
Beilstein:
2230417
EC Number:
MDL number:
UNSPSC Code:
51284017
PubChem Substance ID:
NACRES:
NA.85
Recommended Products
biological source
synthetic
Quality Level
Assay
98.0-102.0% (HPLC)
form
powder or crystals
color
faint yellow to dark yellow
mp
172-174 °C (dec.)
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
InChI
1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
InChI key
OFVLGDICTFRJMM-WESIUVDSSA-N
Gene Information
human ... CYP1A2(1544) , TERT(7015)
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General description
Chemical structure: tetracycline
Biochem/physiol Actions
Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
Packaging
25g, 100g
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.
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Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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How to prepare stock solutions for item 87128-25G, Tetracycline?
1 answer-
Helpful?
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devo fare lo stock della tetraciclina. come e in cosa la devo diluire?
1 answer-
This product is soluble in methanol or ethanol, giving a completely clear solution at up to 30 mg/ml. The stability of this material in solution is pH-dependent. Stock solutions prepared in ethanol are estimated to be stable for 1-3 months when aliquoted and stored at -20°C. Please see the link below to review the product datasheet for T3258, an identical tetracycline product of another brand. The information provided applies to both products.
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/406/734/t3258dat.pdfHelpful?
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