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Silychristin

analytical standard

Synonym(s):

Silymarin II

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About This Item

Empirical Formula (Hill Notation):
C25H22O10
CAS Number:
Molecular Weight:
482.44
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥90.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% water

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1cc(ccc1O)[C@@H]2Oc3c(O)cc(cc3[C@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O

InChI

1S/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1

InChI key

BMLIIPOXVWESJG-LMBCONBSSA-N

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General description

Silychristin is one of the congeners of flavonolignan silybin. It is usually derived from silymarin, which is extracted from the fruits of Silybum marianum (L.) Gaertn, and Asteraceae (Carduus marianus L.; milk thistle).[1]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Silychristin may be used as an analytical reference standard for the determination of silychristin in:
  • Herbal extracts,[2] fruit extracts,[3] and seed extracts[4] of Silybum marianum by ultra-high performance liquid chromatography with diode array detection (UHPLC-DAD)[2][3] and methanol extraction coupled to HPLC equipped with ultraviolet array detection (UVAD).[4]
  • Milk thistle seeds by HPLC-UV.[5]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase.
Fibigr J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 134, 203-213 (2017)
Lijun Duan et al.
Applied biochemistry and biotechnology, 113-116, 559-568 (2004-04-01)
Hot water is attracting attention as an extraction solvent in the recovery of compounds from plant material as the search for milder and "greener" solvents intensifies. The use of hot water as an extraction solvent for milk thistle at temperatures
Ludovico Abenavoli et al.
Phytotherapy research : PTR, 24(10), 1423-1432 (2010-06-22)
Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin
Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice.
Nazir N, et al.
Journal of Ethnopharmacology, 210(7), 198-208 (2018)
Jose F Barreto et al.
Applied biochemistry and biotechnology, 105 -108, 881-889 (2003-05-02)
Milk thistle contains compounds that display hepatoxic protection properties. We examined the batch extraction of silymarin compounds from milk thistle seed meal in 50, 70, 85, and 100 degrees C water as a function of time. After 210 min of

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