04471

(R)-(+)-α-Lipoic acid

analytical standard

• Synonym(s): (R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
• Empirical Formula (Hill Notation): C₈H₁₄O₂S₂
• CAS Number: 1200-22-2
• Molecular Weight: 206.33
• NACRES: NA.24
• PubChem Substance ID: 329747929
• UNSPSC Code: 85151701
• MDL number: MFCD01631142

Properties

• grade: analytical standard
• Quality Segment: 100
• assay: ≥98.0% (HPLC)
• optical activity: [α]/D +115±5°, c = 1% in ethanol
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• mp: 48-52 °C (lit.)
• application(s): cleaning products; cosmetics; food and beverages; personal care
• format: neat
• storage temp.: 2-8°C
• SMILES string: OC(=O)CCCC[C@@H]1CCSS1
• InChI: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
• InChI key: AGBQKNBQESQNJD-SSDOTTSWSA-N

Description

General description

α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.

Application

α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements[1] by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3