Angiotensin-converting enzyme (ACE) is a zinc-metallopeptidase belonging to the peptidase M2 family. It catalyzes the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, which increases the vasoconstrictive effects of angiotensin. The Angiotensin-converting enzyme plays an important role in maintaining cardiac function and vascular tone. It is highly expressed in the heart, lung, kidney, gastrointestinal system, and prostate. Defects in the Angiotensin-converting may contribute cardiac disease; and renal tubular dysgenesis, a condition characterized by persistent fetal anuria and perinatal death.
Evaluated by Western Blot in rat Angiotensin Converting Enzyme.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected rat Angiotensin Converting Enzyme in WB.
Target description
~180 kDa observed. The calculated molecular weight is 150 kDa; however, this protein is known to be glycolsylated.
Linkage
Replaces: MAB3502
Physical form
Mouse monoclonal IgG1 cultured supernatant without preservatives.
Analysis Note
Control Rat Angiotensin Converting Enzyme
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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