AB2256
Anti-GABA B Receptor R1 Antibody
serum, from guinea pig
Synonym(s):
GABA-B receptor, GABA-B receptor 1, GABAB, subunit 1c, gamma-aminobutyric acid (GABA) B receptor 1, gamma-aminobutyric acid B receptor 1, seven transmembrane helix receptor
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
guinea pig
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Gabbr1(54393)
General description
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
Specificity
Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1)
Reactivity with other species has not been determined.
Immunogen
Epitope: C-Terminus
interaction w/ ATF4
interaction w/ ATF4
Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK)
Application
Detect GABA B Receptor R1 using this Anti-GABA B Receptor R1 Antibody validated for use in WB, IH.
Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Quality
Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate.
Target description
~100-105 kDa
Physical form
GST-Depleted Sera with 0.05% NaN3.
Storage and Stability
Stable for 1 year at -20ºC from date of receipt.
Analysis Note
Control
Rat brain lysates
Rat brain lysates
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.
Lancaster, E; Lai, M; Peng, X; Hughes, E; Constantinescu, R; Raizer, J; Friedman et al.
Lancet Neurology null
Camille Mazo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(32), 8289-8304 (2016-08-12)
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The behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result from imbalances in the relative strengths of excitatory and inhibitory neurotransmission. Although modified neuronal excitability is thought to be of significance, the contribution that
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Cell reports, 31(13), 107814-107814 (2020-07-02)
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Sara Mederos et al.
STAR protocols, 3(4), 101667-101667 (2022-09-15)
Here, we present a protocol to selectively downregulate GABAB receptor (GABABR) expression in astrocytes of mouse medial prefrontal cortex (mPFC). We first describe the procedure of surgeries and viral injections. We then detail genetic, histological, and functional characterizations of astrocytic
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