574775-M

Swainsonine, Swainsona canescens

Reversible active-site inhibitor of lysosomal α-mannosidase.

• Synonym(s): Swainsonine, Swainsona canescens, (1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
• Empirical Formula (Hill Notation): C₈H₁₅NO₃
• CAS Number: 72741-87-8
• Molecular Weight: 173.21
• MDL number: MFCD00017554
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 1 mg/mL; DMSO: 5 mg/mL; chloroform: soluble
• storage temp.: 2-8°C
• SMILES string: N21[C@@H]([C@@H]([C@@H](C2)O)O)[C@@H](CCC1)O
• InChI: 1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
• InChI key: FXUAIOOAOAVCGD-WCTZXXKLSA-N

Description

General description

Reversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.

Biochem/physiol Actions

Primary Target
Lysosomal α-mannosidase

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
Elbein, A.D. 1983. Methods Enzymol.98, 135.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3