5.05017

UBP310

• Synonym(s): UBP310, GluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
• Empirical Formula (Hill Notation): C₁₄H₁₅N₃O₆S
• CAS Number: 902464-46-4
• Molecular Weight: 353.35
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• potency: 10 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
• InChI key: ZTAZUCRXCRXNSU-VIFPVBQESA-N

Description

General description

A potent antagonist highly selective for GluK1 (K_b = 10 nM), GluK3 (IC₅₀ = 23 nM), and GluK1/K5 (K_b = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (K_d = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.

Biochem/physiol Actions

Primary Target
GluK1

Secondary Target
Gluk3

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pinheiro, S., et al. 2013. Cereb. Cort.23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol.78, 1036.
Perrais, D., et al. 2009. Neuropharmacol.56, 131.
Dolman, P., et al. 2007. J. Med. Chem.50, 1558.
Mayer, L., et al. 2006. J. Neurosci.26, 2852.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable