480747

Neurogenesis Inducer V, KHS101

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2).

• Synonym(s): Neurogenesis Inducer V, KHS101, N⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine
• Empirical Formula (Hill Notation): C₁₈H₂₁N₅S
• CAS Number: 1262770-73-9
• Molecular Weight: 339.46
• MDL number: MFCD18206916
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: resin (Sticky)
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 100 mg/mL
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: [s]1c(nc(c1)CNc3nc(ccn3)NCC(C)C)c2ccccc2
• InChI: 1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23)
• InChI key: DGRJOOOHPBSAHD-UHFFFAOYSA-N

Description

General description

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC₅₀ ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable