1.11609
Histosec™ pastilles
solidification point 56-58°C embedding agent for histology
Synonym(s):
Embedding agents for microscopy, Embedding agent, Histosec™
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About This Item
UNSPSC Code:
41116124
NACRES:
NA.21
Quality Level
form
solid
potency
>3000 mg/kg LD50, skin (Rabbit)
IVD
for in vitro diagnostic use
transition temp
flash point >100 °C
bulk density
400 kg/m3
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
15-25°C
General description
Histosec™ pastilles - solidification point 56-58 °C embedding agent for histology, is an embedding medium for histology of samples of human origin. it is a paraffin enriched with polymers and containing DMSO (dimethyl sulfoxide). Histosec™ pastilles (without DMSO) (Product number 1.15161) is also available. DMSO (dimethyl sulfoxide) increases the rate of penetration of paraffin and provides additional preservation of the tissue structures. Its melting range is between 56 - 58 °C and, within this range any specimen can be processed without fear of damage irrespective of the method used. In most clinical laboratories the paraffinization is performed with an automated embedding system and is performed directly after the histoprocessing. The Histosec™ pastilles are well soluble with the Intermedia Xylene (isometic mixture) (Cat .no. 108298) or xylene substitutes such as Neo-Clear™(Product number 1.09843).The paraffin is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.
Analysis Note
Solidification point (rotating thermometer method): 56 - 58 °C
Effect of heating (at 60 °C/100 g): clear melt within max. 20 hours
Solubility in xylene (at 20 °C/0.1 g in 5 ml): clear solute within max. 20 hours
Cutting results (4 µm slices): conforms
Solubility of slices in xylene: <50 seconds
Effect of heating (at 60 °C/100 g): clear melt within max. 20 hours
Solubility in xylene (at 20 °C/0.1 g in 5 ml): clear solute within max. 20 hours
Cutting results (4 µm slices): conforms
Solubility of slices in xylene: <50 seconds
Legal Information
HISTOSEC is a trademark of Merck KGaA, Darmstadt, Germany
NEO-CLEAR is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
>212.0 °F
Flash Point(C)
> 100 °C
Certificates of Analysis (COA)
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