07-276
Anti-PDGFRα Antibody
Upstate®, from rabbit
Synonym(s):
Anti-Anti-CD140A, Anti-Anti-PDGFR-2, Anti-Anti-PDGFR2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
packaging
antibody small pack of 25 μL
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Gene Information
human ... PDGFRA(5156)
Related Categories
General description
Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.
Specificity
Recognizes PDGF Receptor alpha.
Immunogen
peptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor α
Application
Detect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Quality
routinely evaluated by immunoblot on 3T3/NIH cell lysate
Target description
150/170 kDa (doublet)
Physical form
ImmunoAffinity Purified
Protein A Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue
HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Evidence for PDGFRA, PDGFRB and KIT deregulation in an NSCLC patient.
T Negri et al.
British journal of cancer, 96(1), 180-181 (2007-01-11)
Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma.
Balyasnikova IV, Ferguson SD, Sengupta S, Han Y, Lesniak MS
Testing null
S Ugurel et al.
British journal of cancer, 92(8), 1398-1405 (2005-04-23)
This two-centre phase-II trial aimed at investigating the efficacy of imatinib in metastasised melanoma patients in correlation to the tumour expression profile of the imatinib targets c-kit and platelet-derived growth factor receptor (PDGF-R). The primary study end point was objective
PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells.
Biswas, SK; Zhao, Y; Nagalingam, A; Gardner, TW; Sandirasegarane, L
Investigative Ophthalmology & Visual Science null
The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1.
Pan, J; Quintas-Cardama, A; Manshouri, T; Giles, FJ; Lamb, P; Tefferi, A; Cortes et al.
Leukemia null
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