857372P

VU0285655-1

N-{2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decan-8-yl]ethyl}quinoline-3-carboxamide, powder

• Synonym(s): APV; VU0285655-1
• Empirical Formula (Hill Notation): C₂₅H₂₇N₅O₂
• CAS Number: 1158347-73-9
• Molecular Weight: 429.51
• MDL number: MFCD22416859
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (857372P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 857372P
• lipid type: bioactive lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O=C(C1=CN=C(C=CC=C2)C2=C1)NCCN(CC3)CCC43N(C5=CC=CC=C5)CNC4=O
• InChI: 1S/C25H27N5O2/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32)
• InChI key: WJOCDBUFEUKYNI-UHFFFAOYSA-N

Description

Application

VU0285655-1 has been used to study its role in membrane type 1 matrix metalloproteinase (MT1-MMP) surface trafficking and lung metastasis of mouse breast cancer cells.[1] It has also been used as a phospholipase D-2 (PLD2) inhibitor to study its role in regulated exocytosis.[2]

Biochem/physiol Actions

VU0285655-1 or N-2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decan-8-yl]ethyl quinoline-3-carboxamide is a phospholipase D-2 (PLD2) inhibitor. It promotes autophagy in colorectal cancer cells.[3]

Packaging

5 mL Amber Glass Screw Cap Vial (857372P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3