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M1641

Sigma-Aldrich

Methoxyphenamine hydrochloride

≥99%

Synonym(s):

2-Methoxy-N,α-dimethylbenzeneethanamine hydrochloride, NSC 65644

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About This Item

Empirical Formula (Hill Notation):
C11H17NO · HCl
CAS Number:
5588-10-3
Molecular Weight:
215.72
EC Number:
226-993-2
MDL number:
MFCD00034832
UNSPSC Code:
12352100
PubChem Substance ID:
57654358
NACRES:
NA.22

Assay

≥99%

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES string

Cl.CNC(C)Cc1ccccc1OC

InChI

1S/C11H17NO.ClH/c1-9(12-2)8-10-6-4-5-7-11(10)13-3;/h4-7,9,12H,8H2,1-3H3;1H

InChI key

FGSJNNQVSUVTPW-UHFFFAOYSA-N

Related Categories

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S D Roy et al.
Clinical pharmacology and therapeutics, 38(2), 128-133 (1985-08-01)
Urine and plasma concentrations of methoxyphenamine (MP) and three of its metabolites were determined after a single oral 60.3 mg dose of MP hydrochloride to healthy subjects of known debrisoquin (D) phenotype. Urine was collected from five extensive (EM) and
Separation of optical isomers of methoxyphenamine and its metabolites as N-heptafluorobutyryl-L-prolyl derivatives by fused-silica capillary gas chromatography.
S D Roy et al.
Journal of chromatography, 431(1), 210-215 (1988-09-23)
Y Nakahara et al.
Forensic science international, 63(1-3), 109-119 (1993-12-01)
The excretion of methoxyphenamine (MOP) and methamphetamine (MA) into beards has been studied. Six healthy male subjects orally took 50 mg of MOP at a single dose and 7 doses for a successive 7 days. Their beard hairs were collected
Mario Thevis et al.
European journal of mass spectrometry (Chichester, England), 14(3), 145-152 (2008-08-19)
Methoxyphenamine (o-methoxy-N,alpha-dimethylphenethylamine, Orthoxine) used in earlier times as a bronchodilator is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA). The drug and several of its metabolites are commonly analysed in doping control screening assays using
R T Coutts et al.
Drug metabolism and disposition: the biological fate of chemicals, 22(5), 756-760 (1994-09-01)
Metabolism of methoxyphenamine (MP) was conducted in vitro using commercially available microsomes prepared from human AHH-1 TK+/-cells in which CYP2D6 had been expressed. This study has confirmed the involvement of CYP2D6 in the metabolism of MP to O-desmethylmethoxyphenamine (ODMP) and
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