Unfortunately, for this product the chiral purity (enantiomeric purity) is not determined. The certificate of analysis for each lot reports the specific rotation; this confirms that the vast majority of the material has the correct (+) chirality. But the ee (enantiomeric excess) is not calculated.
47619
Fmoc-Ser(tBu)-OH
≥98.0% (HPLC), for peptide synthesis
Synonym(s):
Fmoc-O-tert-butyl-L-serine
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€61.00
25 G
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10 G
€61.00
25 G
€89.20
100 G
€315.00
About This Item
Empirical Formula (Hill Notation):
C22H25NO5
CAS Number:
Molecular Weight:
383.44
Beilstein:
3632013
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Recommended Products
Product Name
Fmoc-Ser(tBu)-OH, ≥98.0% (HPLC)
Quality Level
Assay
≥98.0% (HPLC)
form
powder
optical activity
[α]20/D +25.5±1°, c = 1% in ethyl acetate
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
SMILES string
CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
InChI
1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
InChI key
REITVGIIZHFVGU-IBGZPJMESA-N
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Application
Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis.[1] Some of the reported examples are:
- Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.[2]
- Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.[3]
- Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.[4]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What is the chiral purity of Fmoc-Ser(tBu)-OH?
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