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425583

Sigma-Aldrich

p-Tolyl trifluoromethanesulfonate

97%

Synonym(s):

p-Tolyl triflate

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About This Item

Linear Formula:
CF3SO3C6H4CH3
CAS Number:
29540-83-8
Molecular Weight:
240.20
MDL number:
MFCD00192507
UNSPSC Code:
12352100
PubChem Substance ID:
24866645

Assay

97%

refractive index

n20/D 1.441 (lit.)

bp

115 °C/50 mmHg (lit.)

density

1.342 g/mL at 25 °C (lit.)

SMILES string

Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1

InChI

1S/C8H7F3O3S/c1-6-2-4-7(5-3-6)14-15(12,13)8(9,10)11/h2-5H,1H3

InChI key

XXSBXVHIYGQWDV-UHFFFAOYSA-N

General description

p-Tolyl trifluoromethanesulfonate (p-tolyl triflate) is an aryl triflate.

Application

p-Tolyl trifluoromethanesulfonate (p-tolyl triflate) may be used in the asymmetric α-arylation of ketones and arylation of pyridine N-oxide.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Skin Corr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

192.2 °F - closed cup

Flash Point(C)

89 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Direct arylation of azine N-oxides with aryl triflates.
Schipper DJ, et al.
Tetrahedron, 65(26), 4977-4983 (2009)
Xuebin Liao et al.
Journal of the American Chemical Society, 130(1), 195-200 (2007-12-14)
The asymmetric alpha-arylation of ketones with aryl triflates is described, and the use of this electrophile with nickel and palladium catalysts containing a segphos derivative increases substantially the scope of highly enantioselective arylations of ketone enolates. The combination of aryl

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