Skip to Content
Merck
All Photos(1)

Documents

SAB4700229

Sigma-Aldrich

Monoclonal Anti-CD79A antibody produced in mouse

clone HM47, purified immunoglobulin, buffered aqueous solution

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

HM47, monoclonal

form

buffered aqueous solution

species reactivity

pig, human, mouse

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD79A(973)

General description

Cluster of differentiation 79A (CD79A), also known as mb-1 gene, is encoded by the gene mapped to human chromosome 19q13.2-13.3. The encoded protein is characterized with a single extracellular immunoglobulin domain, a transmembrane domain and an intracytoplasmic signaling domain with an immunoreceptor tyrosine-based activation motif (ITAM).
The antibody HM47 interacts with CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.

Immunogen

Synthetic peptide corresponding to amino acids 208-222 of human CD79a

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 79A (CD79A) functions as a highly lineage-specific marker of B lymphoid cells. It also plays a crucial role in the diagnosis of acute leukemia. Mutations in the gene might be a cause of agammaglobulinemia. CD79A acts as an potential biomarker for the detection of B lineage neoplasms.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Giovanna Boi et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 64(1), 18-31 (2015-10-22)
Drying of the tissue section, partial or total, during immunostaining negatively affects both the staining of tissue antigens and the ability to remove previously deposited antibody layers, particularly during sequential rounds of de-staining and re-staining for multiple antigens. The cause
[Prognostic effect of cytoplasmic CD79a expression in acute myeloid leukemia with t(8;21)].
Chung HJ
The Korean Journal of Laboratory Medicine, 27, 388-393 (2007)
CD79a: A Novel Marker for B-Cell Neoplasms in Routinely Processed Tissue Samples
Mason DY
Blood, 86, 1453-1459 (1995)
Structure, chromosomal localization, and methylation pattern of the human mb-1 gene.
Ha H
Journal of Immunology, 152, 5749-5757 (1994)
Mutations in Ig? (CD79a) result in a complete block in B-cell development
Minegishi Y
The Journal of Clinical Investigation, 104, 1115-1121 (1999)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service