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P5669

Sigma-Aldrich

Pyridoxine

≥98%

Synonym(s):

Pyridoxol, Vitamin B6

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3
CAS Number:
65-23-6
Molecular Weight:
169.18
EC Number:
200-603-0
MDL number:
MFCD00006335
UNSPSC Code:
12352104
PubChem Substance ID:
24898690
NACRES:
NA.28

Assay

≥98%

form

powder

technique(s)

HPLC: suitable

color

white to off-white

mp

159-162 °C (lit.)

SMILES string

Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3

InChI key

LXNHXLLTXMVWPM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

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General description

Pyridoxine (vitamin B6) is a form of vitamin B6. Other forms include the aldehyde pyridoxal and the amide pyridoxamine. It is an important cofactor for metabolism.
Vitamin B group are water-soluble and exists in six forms which includes the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phospate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Vitamin B6 is distributed in nuts, whole grains and animal meat.

Application

Pyridoxine has been used as a component of:
  • artificial diet for sugarcane aphid pest
  • modified Strullu and Romand (MSR) medium for carrot root organ culture
  • Luria broth for E coli cultures

Pyridoxine is used in cell culture and other applications as a precursor to pyridoxal phosphate. It has been used as a standard in RP-HPLC (reversed phase high performance liquid chromatography) method. Pyridoxine has been used as a diet supplement to study lipid profile in rats.

Biochem/physiol Actions

Pyridoxine plays a key role in cell maintenance and amino acid metabolism. Deficiency of vitamin B6 leads to anemia especially in pregnant women and seizures in newborns. It serves as cofactor for heme biosynthesis during δ-amino levulinic acid formation, γ-aminobutyric acid (GABA) transaminase and glutamic acid decarboxylase. Vitamin B6 also helps in reactive oxygen species (ROS) scavenging and helps plants in overcoming the abiotic and biotic stress.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E B Rimm et al.
JAMA, 279(5), 359-364 (1998-02-12)
Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available. To examine intakes of folate and
Simultaneous high performance liquid chromatographic analysis of vitamins B1, B2 and B6 in royal jelly
Ana Elisa Presoto
Journal of the Brazilian Chemical Society, 15(1), 136-139 (2004)
Pediatric Critical Care, 306(20), 2269-2269 (2011)
Nutrition and anemia in end-stage renal disease
Nutritional Management of Renal Disease, 383-391 (2013)
Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review
Tong Y
Intractable & rare diseases research, 3(2), 52-56 (2014)
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