14-309
PCAF Protein, Active, 50 µg
PCAF recombinant GST fusion protein, for use in Histone Acetyltransferase Assays. (HAT).
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About This Item
Recommended Products
recombinant
expressed in E. coli
Quality Level
mol wt
Mw 79 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (histone acetyltransferase (HAT))
NCBI accession no.
UniProt accession no.
shipped in
dry ice
General description
Product Source: expressed in E. Coli corresponding to amino acids 352-832
Quality
routinely evaluated by acetylation of core histones in vitro
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Molecular and cellular biology, 29(5), 1321-1337 (2008-12-24)
Special AT-rich binding protein 1 (SATB1) acts as a global regulator of gene expression by recruiting various corepressor or coactivator complexes, thereby establishing a unique chromatin structure at its genomic targets in a context-dependent manner. Although SATB1 acts predominantly as
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 4107-4123 (2018-12-12)
The epigenetic enzyme p300/CBP-associated factor (PCAF) belongs to the GCN5-related N-acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post-translational function is well characterized, little is known about its properties as regulator of cell metabolism. Here, we report the
Journal of enzyme inhibition and medicinal chemistry, 31(sup3), 75-82 (2016-07-09)
Histones and polyamines are important determinants of the chromatin structure. Histones form the core of nucleosome particles and their modification by acetylation of N-terminal tails is involved in chromatin structural changes and transcriptional regulation. Polyamines, including spermidine, are also targets
The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates
Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.
The Embo Journal null
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