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A16602

Sigma-Aldrich

DL-N-Acetylhomocysteine thiolactone

98%

Synonym(s):

2-Acetamido-4-mercaptobutyric acid γ-thiolactone

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About This Item

Empirical Formula (Hill Notation):
C6H9NO2S
CAS Number:
1195-16-0
Molecular Weight:
159.21
EC Number:
214-793-8
MDL number:
MFCD00005480
UNSPSC Code:
12352100
PubChem Substance ID:
24890578
NACRES:
NA.22

Assay

98%

form

powder

mp

109-111 °C (lit.)

SMILES string

CC(=O)NC1CCSC1=O

InChI

1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)

InChI key

NRFJZTXWLKPZAV-UHFFFAOYSA-N

Application

<ul>
<li><strong>Ultrasonic synthesis of stable oil filled microcapsules:</strong> This study explores the ultrasonic synthesis of oil-filled microcapsules using thiolated chitosan, potentially involving derivatives like N-Acetylhomocysteine thiolactone for improved stability and functional properties. The research provides insights into advanced microencapsulation techniques relevant in pharmaceutical and industrial applications (

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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M de Barrio et al.
Journal of investigational allergology & clinical immunology, 7(3), 193-194 (1997-05-01)
Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on
U J Eriksson et al.
Diabetologia, 34(5), 325-331 (1991-05-01)
This study addresses the possibility that the teratogenic effects of a diabetic pregnancy are associated with increased embryonic activities of free oxygen radicals. Rat embryos were cultured in 50 mmol/l glucose for 48 h and subsequently showed pronounced growth retardation
W Sumoski et al.
Diabetologia, 32(11), 792-796 (1989-11-01)
A possible role for oxygen free radicals in mediating the cytotoxic effects of cytokines in islets was sought by the use of agents that scavenge free radicals. Rat islet cell monolayer cultures were incubated for 6 days with t-butylhydroperoxide, alloxan
P P Sood et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 14(2), 101-105 (1995-01-01)
Male albino mice were intoxicated with a daily dose of 1 mg/kg of methylmercury chloride (MMC) for 7 days, and were treated thereafter with glutathione, N-acetyl-DL-homocysteine thiolactone, vitamin B complex, and vitamin E, either alone or in combinations, for the
I Flechner et al.
Diabetes research (Edinburgh, Scotland), 13(2), 67-73 (1990-02-01)
The possible value of radical scavengers in the prevention of beta cell destruction was studied in two animal models of type I diabetes. Eight compounds were tested alone or in combinations. In the low-dose streptozotocin model treatment started 24 hr
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