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939692

Sigma-Aldrich

Poly(glycerol sebacate) methacrylate

new

degree of methacrylation 20%, contains 150 ppm MEHQ as inhibitor

Synonym(s):

PGS-MA

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About This Item

Linear Formula:
[CH2CH(O2C4H5)CH2OOC(CH2)8COO]n
UNSPSC Code:
12352201

Quality Level

form

(liquid/paste)

contains

150 ppm MEHQ as inhibitor

color

white/yellow

storage temp.

−20°C

General description

Poly(glycerol sebacate) methacrylate (PGS-MA) is a photopolymerizable biodegradable elastomer with tunable mechanical properites that can be used for bioprinting, tissue engineering, and regenerative medicine applications including cardiac, nerve, and muscle tissues. PGS is derived from the naturally occuring metabolites glycerol and sebacic acid, which have both been used for FDA approved biomedical applications. The polymer backbone contains ester bonds that can undergo hydrolytic degradation and can also be covalently crosslinked to form a 3D network at higher temperatures under vacuum. The addition of the methacrylate functional groups provides another mechanism of crosslinking via photopolymerization. The PGS-MA can be quickly and efficiently crosslinked under the exposure of UV and visible light in the presence of a photoinitiatior.

Application

  • Soft tissue engineering such as blood vessels, cornea and nerve tissue
  • Orthopedic implants and regenerative medicine application like muscle tissues
  • Nanoparticle formulation and drug delivery systems
  • Flexible wearable or implantable bioelectronic applications

Features and Benefits

  • Flexible elastomer with tunable mechanical properties
  • Higher reversible deformation properties
  • Shape memory
  • Bioresorbable polymer

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Synthesis, Characterization and 3D Micro-Structuring via 2-Photon Polymerization of Poly(glycerol sebacate)-Methacrylate?An Elastomeric Degradable Polymer
Pashneh-Tala S, et al
Frontiers in physics, 6 (2018)
Poly(Glycerol Sebacate) in Biomedical Applications?A Review of the Recent Literature
Vogt L, et al
Advanced Healthcare Materials, 10, 2002026-2002026 (2021)

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