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914487

Sigma-Aldrich

2-(Diphenylphosphanyl)benzamide

≥95%

Synonym(s):

2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction

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About This Item

Empirical Formula (Hill Notation):
C19H16NOP
CAS Number:
Molecular Weight:
305.31
UNSPSC Code:
12352200
NACRES:
NA.22

Quality Level

Assay

≥95%

form

powder

storage temp.

−20°C

General description

It is recommended to make fresh stock stolutions prior to each use.

Application

2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N3 (cat# 913812).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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Shao-Ru Wang et al.
Nature communications, 11(1), 91-91 (2020-01-05)
Prokaryotes use repetitive genomic elements termed CRISPR (clustered regularly interspaced short palindromic repeats) to destroy invading genetic molecules. Although CRISPR systems have been widely used in DNA and RNA technology, certain adverse effects do occur. For example, constitutively active CRISPR

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