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Sigma-Aldrich

Cyanoborohydride, polymer supported

macroporous, 20-50 mesh, extent of labeling: ~2.0-3.5 mmol/g loading

Synonym(s):

Cyanoborohydride on Amberlite IRA-400

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About This Item

UNSPSC Code:
12352117
PubChem Substance ID:
NACRES:
NA.22

form

macroporous

Quality Level

reaction suitability

reaction type: solution phase peptide synthesis
reactivity: imine reactive

extent of labeling

~2.0-3.5 mmol/g loading

particle size

20-50 mesh

mp

>300 °C (lit.)

storage temp.

2-8°C

General description

Cyanoborohydride, polymer supported: is a polymer-supported reducing agent used in reductive amination reactions at room temperature.

Application

Polymer supported cyanoborohydride (PSCBH) has been used in the reductive alkylation aminocyclitols for the preparation of corresponding secondary amines.
It can also be used:
  • In combination with manganese dioxide (MnO2) for one-pot conversion of alcohols to secondary or tertiary amines.
  • In the synthesis of natural products, (±)-oxomaritidine and (±)-epimaritidine.

Legal Information

Amberlite is a trademark of DuPont de Nemours, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In situ oxidation- imine formation- reduction routes from alcohols to amines
Blackburn L and Taylor RJK
Organic Letters, 3(11), 1637-1639 (2001)
Small-Scale One-Pot Reductive Alkylation of Unprotected Aminocyclitols with Supported Reagents
Sisa M, et al.
Synthesis, 2008(19), 3167-3170 (2008)
Ley, S.V.
J. Chem. Soc., Perkin Trans., 2239-2239 (1998)
Synthesis of the alkaloids (?)-oxomaritidine and (?)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents
Ley S, et al.
Journal of the Chemical Society. Perkin Transactions 1, 3(10), 1251-1252 (1999)
Habermann, J.
J. Chem. Soc., Perkin Trans., 3127-3127 (1998)

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