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Key Documents

133337

Sigma-Aldrich

4-Acetamidobenzoic acid

98%

Synonym(s):

N-Acetyl-PABA

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About This Item

Linear Formula:
CH3CONHC6H4CO2H
CAS Number:
Molecular Weight:
179.17
Beilstein:
390602
EC Number:
MDL number:
UNSPSC Code:
12352106
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

mp

259-262 °C (dec.) (lit.)

application(s)

peptide synthesis

SMILES string

CC(=O)Nc1ccc(cc1)C(O)=O

InChI

1S/C9H9NO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13)

InChI key

QCXJEYYXVJIFCE-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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João Neres et al.
Bioorganic & medicinal chemistry, 15(5), 2106-2119 (2007-01-16)
Benzoic acid and pyridine derivatives inhibit recombinant trans-sialidase from Trypanosoma cruzi with I50 values between 0.4 and 1mM. The best compounds, 4-acetylamino-3-hydroxymethylbenzoic acid and 5-acetylamino-6-aminopyridine-2-carboxylic acid, provide new leads to inhibitors not containing the synthetically complex sialic acid structure. The
K N Furuya et al.
Clinical biochemistry, 28(5), 531-540 (1995-10-01)
To evaluate glycine conjugation of para-aminobenzoic acid (PABA) to the hippurated metabolites, para-aminohippuric acid (PAHA), and para-acetamidohippuric acid (PAAHA) as a quantitative liver function test in patients with liver disease. Serum concentrations of PABA and metabolites were measured by high
In vitro histamine release induced by radiocontrast media and various chemical analogs in reactor and control subjects.
M C Rice et al.
The Journal of allergy and clinical immunology, 72(2), 180-186 (1983-08-01)
Reversed-phase high-performance liquid chromatographic assay for the determination of the in vitro acetylation of p-aminobenzoic acid by human whole blood.
R M Lindsay et al.
Journal of chromatography, 433, 292-297 (1988-12-09)
B Barbieri et al.
Thrombosis research, 95(5), 235-243 (1999-10-09)
We have previously found that the naturally occurring amine p-aminobenzoic acid (PABA) inhibits the thrombin-induced thromboxane B2 production in human platelets. In this report we show that PABA and its acetylated metabolite p-acetamidobenzoic acid (PACBA) inhibit platelet aggregation induced by

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