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CRM03908

Supelco

Spirodiclofen

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonym(s):

3-(2,4-Dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl) 2,2-dimethylbutyrate

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About This Item

Empirical Formula (Hill Notation):
C21H24Cl2O4
CAS Number:
Molecular Weight:
411.32
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
TraceCERT®

Quality Level

product line

TraceCERT®

form

powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

SMILES string

CCC(C)(C)C(=O)OC1=C(C(=O)OC12CCCCC2)c3ccc(Cl)cc3Cl

InChI

1S/C21H24Cl2O4/c1-4-20(2,3)19(25)26-17-16(14-9-8-13(22)12-15(14)23)18(24)27-21(17)10-6-5-7-11-21/h8-9,12H,4-7,10-11H2,1-3H3

InChI key

DTDSAWVUFPGDMX-UHFFFAOYSA-N

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General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.

Spirodiclofen is a selective, non-systemic acaricide belonging to the new family of spirocyclic tetronic acids (keto-enols). It is highly active against spider mites, such as Panonychus, Tetranychus, Phyllocoptruta, Brevipalpus, and Aculus species in citrus, pome fruits, grapes, and nuts. Spirodiclofen targets lipid biosynthesis by inhibiting acetyl-coenzyme A carboxylase (ACCase) and it effectively controls the population of mites resistant to other acaricides.

Spirodiclofen has to be monitored in the Multiannual Control Programmes for Pesticides Residues (MACP), run within the EU and EFTA in/on products of plant origin. Maximum residue levels (MRLs) have been set according to Reg (EG) No 2016/1902 for spirodiclofen for various products of plant and animal origin from 0.004 to 2 mg/kg.

Spirodiclofen was initially included in Annex I to Directive 91/414/EEC on 1 August 2010 and is approved under Regulation (EC) No 1107/2009, following Commission Implementing Regulation (EU) No 540/2011. However, after its approval expired on 31 July 2020, Spirodiclofen is no longer approved in the European Union (EU) but is authorized in third countries for use on citrus fruits that might be fed to livestock.

Application

It is intended to be used as a certified reference material (CRM) for calibration in chromatography and other analytical techniques. Spirodiclofen CRM may also find its use as follows:
  • Study the molecular mechanisms of spirodiclofen resistance using two highly resistant Tetranychus urticae strains with different genetic backgrounds
  • To evaluate the sublethal effects of spirodiclofen, abamectin, and pyridaben on life-history traits and life-table parameters of two-spotted spider mites, Tetranychus urticae
  • To evaluate the effect of a combination of spirodiclofen with other insecticides for the control of Brevipalpus yothersi in citrus
  • Investigate the effects of salicylic acid treatment of tomato plants on the susceptibility of Tetranychus urticae to spirodiclofen, the activities of mite digestive enzymes, and its energy reserves
  • Simultaneous determination of spirodiclofen, spiromesifen, and spirotetramat and their metabolites in edible fungi using a modified QuEChERS procedure and UHPLC-MS/MS

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 1 - Carc. 1B - Repr. 2 - Skin Sens. 1B - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Mohammad Homayoonzadeh et al.
Experimental & applied acarology, 82(3), 319-333 (2020-10-18)
Salicylic acid (SA) is a signaling molecule that can induce plant resistance to certain herbivores. Although the role of jasmonic acid in mediating mite-tomato plant interactions has been well studied, the role of salicylic acid has not. This study examined
Spirodiclofen and Spiromesifen
Nauen R, et al.
Pesticide Outlook, 243-246 null
Moosa Saber et al.
Experimental & applied acarology, 75(1), 55-67 (2018-03-10)
Two-spotted spider mite, Tetranychus urticae Koch, is one of the economically most important pests on a wide range of crops in greenhouses and orchards worldwide. Control of T. urticae has been largely based on the use of acaricides. Sublethal effects
Peter Demaeght et al.
Insect biochemistry and molecular biology, 43(6), 544-554 (2013-03-26)
Spirodiclofen is one of the most recently developed acaricides and belongs to the new family of spirocyclic tetronic acids (ketoenols). This new acaricidal family is an important chemical tool in resistance management strategies providing sustainable control of spider mites such
Fajun Tian et al.
Scientific reports, 11(1), 1547-1547 (2021-01-17)
A fast, sensitive, and reliable analytical method was developed and validated for simultaneous identification and quantification of spirodiclofen, spiromesifen, and spirotetramat and their relevant metabolites in edible fungi by ultra-performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS). First, sample extraction was done

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