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Key Documents

SRP8044

Sigma-Aldrich

CD40L, Soluble human

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Synonym(s):

ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

biological source

human

recombinant

expressed in CHO cells

tag

FLAG® tagged

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

35-40 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.01 EU/μg endotoxin, tested

UniProt accession no.

P29965

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CD40LG(959)

General description

CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form.

Biochem/physiol Actions

CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients.

Physical form

Lyophilized from PBS

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex.
Holler N, et al.
Molecular and Cellular Biology, 23(4), 1428-1440 (2003)
Association between Serum Soluble CD154 Levels and Mortality in Patients with Malignant Middle Cerebral Artery Infarction.
Lorente L, et al.
International Journal of Molecular Sciences, 16(6), 12147-12158 (2015)

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