SAB4700142

Monoclonal Anti-CD80-FITC antibody produced in mouse

clone MEM-233, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-B7-1
• UNSPSC Code: 12352203
• NACRES: NA.44

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: FITC conjugate
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: MEM-233, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_005191.3
• UniProt accession no.: P33681
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... CD80(941)

Description

General description

Cluster of differentiation 80 (CD80), also called as lymphocyte activation antigen 7-1, is encoded by the gene mapped to human chromosome 3q13.33. The encoded protein is mainly expressed on antigen presenting cells such as, neutrophils, macrophages and dendritic cells.

The antibody MEM-233 reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

Immunogen

Extracellular domain of human CD80 fused to human IgG1(Fc)

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Biochem/physiol Actions

Cluster of differentiation 80 (CD80) interacts with its ligand, co-stimulator ligand CD28 or with cytotoxic T-lymphocyte protein 4 (CTLA-4) and facilitates the regulation of CD4⁺ and CD8⁺ T cell activity. Elevated urinary CD80 excretion leads to Fabry disease. CD80, which is expressed on surface of dendritic cells acts as a key co-stimulatory molecule and induces second signal for the proper stimulation of cancer antigen-specific naive T cells.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable