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SAB4504671

Sigma-Aldrich

Anti-phospho-DDR1 (pTyr513) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CAK, Anti-CD167, Anti-DDR, Anti-EDDR1, Anti-HGK2, Anti-MCK10, Anti-NEP, Anti-NTRK4, Anti-PTK3, Anti-RTK6, Anti-TRKE

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 101 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr513)

Gene Information

human ... DDR1(780)

General description

Discoidin domain receptor I (DDR1) is a receptor tyrosine kinase (RTK)/collagen-activated tyrosine kinase, that is located on human chromosome 6p21.

Immunogen

The antiserum was produced against synthesized peptide derived from human DDR1 around the phosphorylation site of Tyr513.

Immunogen Range: 479-528

Biochem/physiol Actions

Discoidin domain receptor I (DDR1) plays important roles in several cancers. In renal cancer cells, DDR1 promotes epithelial to mesenchymal transition. It also increases invasion and metastasis of gastric cancer through epithelial-mesenchymal transition.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells
Song J, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(8), 11509-11521 (2016)
Receptor protein tyrosine kinase DDR is up-regulated by p53 protein
Sakuma S, et al.
Febs Letters, 398(2-3), 165-169 (1996)
DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition
Xie R, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 12049-12059 (2016)
Aveline Filliol et al.
Nature, 610(7931), 356-365 (2022-10-06)
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease and advanced fibrosis1,2. Here we interrogated functions of hepatic stellate cells (HSCs), the main source of liver fibroblasts3, during hepatocarcinogenesis. Genetic

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