This chemical can be stored in solution at -80°C for 6 months and at -20°C for 1 month (protect from light).
PZ0383
Palbociclib
≥98% (HPLC), powder, CDK 4 & 6 inhibitor
Synonym(s):
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, Ibrance, PD 0332991, PD 332991, PD-0332991, PD0332991, PD991, PF 00080665, PF-00080665, PF00080665
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About This Item
Empirical Formula (Hill Notation):
C24H29N7O2
CAS Number:
Molecular Weight:
447.53
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
Product Name
Palbociclib, ≥98% (HPLC)
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
0.1 M HCl: 2 mg/mL, clear
storage temp.
room temp
SMILES string
CC(C1=C(N2C3CCCC3)N=C(NC4=CC=C(N5CCNCC5)C=N4)N=C1)=C(C(C)=O)C2=O
InChI
1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChI key
AHJRHEGDXFFMBM-UHFFFAOYSA-N
Biochem/physiol Actions
PF-00080665 (Palbociclib; PD 0332991) is an orally active and highly specific inhibitor against cyclin-dependent kinase 4 & 6 (IC50 = 9, 11, 15 nM, respectively, using CDK4/cycD3, CDK4/cycD1, CDK6/cycD2; IC50 >10 μM against 36 other kinases) that potently suppresses Cdk4/6-dependent cellular Rb phosphorylation (IC50 = 66 nM/pSer780 & 63 nM/pSer795; MDA-MB-435). PF-00080665 exhibits selective antiproliferation activity against Rb-positive human breast/colon/lung/leukemia cancer cultures (IC50 = 40-400 nM; IC50 >3 μM/Rb-negative MDA-MB-468 & H2009) and displays in vivo efficacy against various advanced stage human tumor xenografts in mice (12.5-150 mg/kg/day p.o.).
Storage and Stability
This chemical can be stored in solution at -80°C for 6 months and at -20°C for 1 month (protect from light).
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Muta. 2 - Repr. 2 - STOT RE 2 Oral
Target Organs
Bone marrow,male reproductive organs
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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dopo averlo sciolto in 0.1 M HCl, a che temperatura va conservato? va evitato congela e scongela delle aliquote?
1 answer-
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