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N144

Sigma-Aldrich

Nitrendipine

>95%, powder

Synonym(s):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

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About This Item

Empirical Formula (Hill Notation):
C18H20N2O6
CAS Number:
39562-70-4
Molecular Weight:
360.36
EC Number:
254-513-1
MDL number:
MFCD00082255
UNSPSC Code:
12352200
PubChem Substance ID:
24277857
NACRES:
NA.77

Assay

>95%

form

powder

color

yellow to green

solubility

methanol: 15 mg/mL
DMSO: 17.5 mg/mL
H2O: insoluble

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC

InChI

1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

InChI key

PVHUJELLJLJGLN-UHFFFAOYSA-N

Gene Information

human ... ADORA3(140) , CACNG1(786) , KCNH1(3756) , TTR(7276)
rat ... Adora1(29290) , Adora2a(25369)

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Biochem/physiol Actions

Ca2+ channel blocker; anti-hypertensive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Yanhua Liu et al.
Arzneimittel-Forschung, 61(12), 674-680 (2012-01-28)
A rapid, sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of nitrendipine (NTD, CAS 39562-70-4) in dog plasma. Using propranolol hydrochloride (CAS 318-98-9) as an internal standard (IS), plasma samples
Xi Zhang et al.
International journal of pharmaceutics, 431(1-2), 45-52 (2012-05-01)
A novel active and multi-dose dry powder inhaler (DPI) was developed and evaluated to deliver a small quantity (100-500 μg) of pure drug without any excipient. This dry powder inhaler utilized two compressed air flows to dispense and deliver drug
Annik Bergeron et al.
Bioanalysis, 4(8), 897-908 (2012-04-27)
In the past several years, the impact of changing counter ions while keeping the same anticoagulant in bioanalytical LC-MS/MS methods has become a highly discussed topic. In order to confirm that there is no impact from counter ions, matrix effect
Jian X Wu et al.
International journal of pharmaceutics, 433(1-2), 60-70 (2012-05-09)
This study focuses on the development of an automated image analysis method to extract information on nucleation and crystal growth from polarized light micrographs. Using the developed image analysis method, four parameters related to nucleation and crystal growth could be
Peng Quan et al.
AAPS PharmSciTech, 12(4), 1136-1143 (2011-09-06)
The present investigation was undertaken with the objective of developing a solid formulation containing nitrendipine nanocrystals for oral delivery. Nitrendipine nanocrystals were prepared using a tandem precipitation-homogenization process. Then, spray drying, a cost-effective method very popular in industrial situations, was
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