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G0885

Sigma-Aldrich

Glycogen from bovine liver

≥85% dry basis (enzymatic)

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About This Item

Linear Formula:
(C6H10O5)n
CAS Number:
9005-79-2
EC Number:
232-683-8
MDL number:
MFCD00081547
UNSPSC Code:
12352201
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

bovine liver

Quality Level

200

Assay

≥85% dry basis (enzymatic)

form

powder

color

white to off-white

storage temp.

2-8°C

InChI

1S/C24H42O21/c25-1-5-9(28)11(30)16(35)22(41-5)39-4-8-20(45-23-17(36)12(31)10(29)6(2-26)42-23)14(33)18(37)24(43-8)44-19-7(3-27)40-21(38)15(34)13(19)32/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10-,11+,12+,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-/m1/s1

InChI key

BYSGBSNPRWKUQH-UJDJLXLFSA-N

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General description

Glycogen is a branched polymer of glucose synthesized by animal cells for energy storage and release. It is constructed of predominantly α1→4 glycosidic bonds with branches created through α1→6 glycosidic bonds.

Application

Glycogen from bovine liver may be used in carbohydrate storage and metabolism research and to study various enzymes such as alpha-glucosidase(s) (GAA) and glycogen phosphorylase(s) (GPase).[1] Glycogen may be used as a substrate to identify and characterize its metabolizing enzymes.[1]

Preparation Note

Prepared by a modification of the procedure of Bell, et al., Biochem. J., 28, 882 (1934).

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000367342
0000367344
0000315788
0000315781
0000315782

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Istvan Katona et al.
Orphanet journal of rare diseases, 9, 17-17 (2014-02-06)
Glycogenosis type II or Pompe disease is an autosomal-recessive lysosomal storage disease due to mutations in the gene encoding acid alpha-glucosidase (GAA), an enzyme required for lysosomal glycogen degradation. The disease predominantly affects the skeletal and respiratory muscles but there
Louise Knudsen et al.
PloS one, 7(12), e51972-e51972 (2013-01-10)
Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new insulin analogues. The occurrence
Marion Curtis et al.
Cell metabolism, 29(1), 141-155 (2018-09-04)
Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable isotope labeling of amino acids in cell culture coupled with quantitative, label-free phosphoproteomics to study the bidirectional signaling in ovarian cancer cells and human-derived, cancer-associated fibroblasts (CAFs) after
Maria Kylä-Puhju et al.
Meat science, 69(1), 143-149 (2005-01-01)
The activity of glycogen debranching enzyme (GDE) was studied in relation to pH value and temperature in porcine masseter and longissimus dorsi muscles. A glycogen limit dextrin was used as the substrate for GDE, and the enzyme was derived from
Sonya V Iverson et al.
Free radical biology & medicine, 63, 369-380 (2013-06-08)
Besides helping to maintain a reducing intracellular environment, the thioredoxin (Trx) system impacts bioenergetics and drug metabolism. We show that hepatocyte-specific disruption of Txnrd1, encoding Trx reductase-1 (TrxR1), causes a metabolic switch in which lipogenic genes are repressed and periportal
View All Related Papers

Questions

1–6 of 6 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the solubility of Product G0885, Glycogen from Bovine Liver?

    1 answer

    1. Sigma routinely tests the solubility in water at 50 mg/mL, yielding a hazy solution. In general, glycogens are soluble in water with opalescence and insoluble in alcohol.

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  4. What are glycogens?

    1 answer

    1. Per Biochemistry, Lehninger ed., 2nd ed, p. 266: A general description of glycogens is: A polymer of alpha (1->4) linked D-Glucose with alpha (1->6) branching at about ever 8 to 12 glucose residues. The molecular weight for bovine source is not mentioned, but glycogen in general is 270,000-3.5 million.

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  5. What is the specific rotation of Product G0885, Glycogen from Bovine Liver?

    1 answer

    1. The specific rotation of this product is +196° to +197°.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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