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23131

Sigma-Aldrich

Ethyl chloroformate

purum, ≥98.0% (GC)

Synonym(s):

Chloroformic acid ethyl ester

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About This Item

Linear Formula:
ClCOOC2H5
CAS Number:
Molecular Weight:
108.52
Beilstein:
385653
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.74 (vs air)

Quality Level

vapor pressure

3.42 psi ( 20 °C)

grade

purum

Assay

≥98.0% (GC)

form

liquid

autoignition temp.

842 °F

refractive index

n20/D 1.395 (lit.)
n20/D 1.396

bp

93 °C (lit.)

mp

−81 °C (lit.)

density

1.139 g/mL at 20 °C
1.135 g/mL at 25 °C (lit.)

SMILES string

CCOC(Cl)=O

InChI

1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3

InChI key

RIFGWPKJUGCATF-UHFFFAOYSA-N

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Application

  • GC-MS Analysis of Resveratrol Isomers in Red Wine: Application of ethyl chloroformate for derivatization of resveratrol isomers, enhancing GC-MS analysis effectiveness, crucial for quality control in food chemistry and drug discovery focusing on dietary supplements (Di Fabio et al., 2020).
  • Determination of Free Aromatic Carboxylic Acids and Phenols in Juices: Uses ethyl chloroformate for rapid GC-MS analysis, important for food safety and pharmacology by verifying phenolic bioactive compounds in consumer products (Incocciati et al., 2021).
  • Synthesis of Diaryl Ketones: Discusses a nickel-catalyzed method of synthesizing diaryl ketones using ethyl chloroformate, valuable for material science chemists developing new materials and pharmaceutical compounds (Shi & Hu, 2019).

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

60.8 °F

Flash Point(C)

16 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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P Husek et al.
Journal of chromatography. B, Biomedical sciences and applications, 693(2), 499-502 (1997-06-06)
Following deproteinization of plasma with organic solvents the supernatant was shaken with hexane and cation-exchange resin in an Eppendorf tube to remove fatty and amino acids and the medium was subjected to direct treatment with ethyl chloroformate under catalytic influence
Mohana Krishna Reddy Mudiam et al.
Analytical and bioanalytical chemistry, 401(5), 1695-1701 (2011-07-12)
A simple and rapid analytical method based on in-matrix ethyl chloroformate (ECF) derivatization has been developed for the quantitative determination of bisphenol-A (BPA) in milk and water samples. The samples containing BPA were derivatised with ECF in the presence of
Guo-Xiang Xie et al.
Journal of pharmaceutical and biomedical analysis, 43(3), 920-925 (2006-10-13)
Dencichine (beta-N-oxalyl-l-alpha,beta-diaminopropionic acid) is a haemostatic agent present in well-known traditional Chinese medicinal herbs such as Panax notoginseng, as well as other Panax species. It is also a reported neurotoxic agent found in Lathyrus sativus (grass pea seed) and cycad
Man-Jeong Paik et al.
Journal of chromatography. A, 1214(1-2), 151-156 (2008-11-11)
N-ethoxycarbonylation was combined with (S)-1-phenylethylamidation for enantioseparation of amino acids by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) on achiral capillary columns. The method provided complete enantioseparations of 12 amino acids as diastereomeric N-ethoxycarbonyl/(S)-1-phenylethylamides with exceptional resolutions for proline
Jinmao You et al.
Analytica chimica acta, 658(1), 98-105 (2010-01-20)
An improved reagent named 2-[2-(dibenzocarbazole)-ethoxy] ethyl chloroformate (DBCEC-Cl) for the determination of aliphatic amines by high-performance liquid chromatography (HPLC) with fluorescence detection and post-column online atmospheric chemical ionization-mass spectrometry (APCI-MS) identification has been developed. DBCEC-Cl could easily and quickly label

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