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Key Documents

C-007

Supelco

Codeine-D3 solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H18D3NO3
CAS Number:
Molecular Weight:
302.38
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

[2H]C([2H])([2H])N1CC[C@]23[C@H]4Oc5c(OC)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35

InChI

1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1/i1D3

InChI key

OROGSEYTTFOCAN-SBGSAQJDSA-N

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General description

Codeine-D3 is a stable-labeled internal standard suitable for many LC/MS or GC/MS testing applications including pain prescription monitoring, forensic analysis, clinical toxicology, urine drug testing or isotope dilution methods. Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. Since opiate drugs are classified as controlled substances, Cerilliant offers most opiate reference standards as DEA-exempt solutions for added convenience.

Application

<ul>
<li><strong>Codeine-D3 analytical standard in opioid detection:</strong> Codeine-D3 is used as an internal standard for the accurate determination of opioids in blood and pericardial fluid, enhancing forensic and clinical toxicology analyses (Ferreira et al., 2020).</li>
<li><strong>Deuterated codeine for research in plasma opioid quantification:</strong> Comparison of mass spectrometry techniques using Codeine-D3 to quantify opioids in human plasma highlights its application in enhancing the sensitivity and specificity of pharmacokinetic studies (Viaene et al., 2016).</li>
<li><strong>Codeine isotopic label in urinary opiate analysis:</strong> An LC-MS method was validated using Codeine-D3, proving its efficacy in the accurate determination of urinary opiate metabolites, thereby supporting drug monitoring and compliance testing (Svensson et al., 2007).</li>
<li><strong>High-purity Codeine-D3 for biochemistry research:</strong> Codeine-D3 was crucial in validating a direct injection electrospray LC-MS/MS technique for opiates in urine drug testing, underscoring its utility in clinical diagnostics and forensic investigations (Gustavsson et al., 2007).</li>
</ul>

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


Certificates of Analysis (COA)

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