D5146
Diazolidinyl urea
≥95%
Synonym(s):
1-[1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea, Diazolidinylurea, N-Hydroxymethyl-N-[1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N′-hydroxymethylurea, N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N′-bis(hydroxymethyl)urea
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C8H14N4O7
CAS Number:
Molecular Weight:
278.22
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O
InChI
1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18)
InChI key
SOROIESOUPGGFO-UHFFFAOYSA-N
General description
Diazolidinyl urea is urea derivative that is commonly used as a preservative and antimicrobial agent in cosmetics and personal care products.
Application
- Impact of cosmetic preservatives on skin cells: A study examined the effects of various cosmetic preservatives, including Diazolidinyl Urea, on healthy human skin cells, highlighting the cellular responses and potential implications for skin health (Głaz et al., 2023).
- Formaldehyde releasers in personal care: An extensive clinical review discussed allergic contact dermatitis caused by formaldehyde and formaldehyde releasers such as Diazolidinyl Urea, providing insights into allergic reactions and safety concerns in dermatological practice (Goossens and Aerts, 2022).
- Carcinogenic potential of cosmetic ingredients: Research on potential carcinogens in makeup cosmetics included Diazolidinyl Urea, emphasizing the safety and regulatory aspects concerning its use in cosmetic formulations (Balwierz et al., 2023).
- Patch testing for allergen sensitivity: A study integrated Diazolidinyl Urea in a patch test series to evaluate skin sensitization and allergic reactions in patients, aiding in the assessment of its allergenic potential (Bizjak et al., 2022).
Disclaimer
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography
Williams III, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 696, 303-306 (1997)
Diazolidinyl urea: incidence of sensitivity, patterns of cross?reactivity and clinical relevance.
Hectorne KJ & Fransway AF
Contact Dermatitis, 30(1), 16-19 (1994)
Microbial inhibitors for U.S. EPA drinking water methods for the determination of organic compounds.
S D Winslow et al.
Environmental science & technology, 35(20), 4103-4110 (2001-11-01)
Preservation of chemical analytes in drinking water samples is necessary to obtain accurate information concerning contaminant occurrence. Sample preservation to prevent biodegradation is important for most samples and analytes. With the unique demands of environmental methods, it is not always
A T Karlberg et al.
Contact dermatitis, 38(1), 20-28 (1998-03-21)
Reliable and uncomplicated methods for detection of free formaldehyde in products preserved with formaldehyde donors are desirable to decrease the risk of allergic contact dermatitis. The aim of this study was to develop a method that could be used in
Claus Zachariae et al.
Contact dermatitis, 53(5), 268-277 (2005-11-15)
The elicitation potential of the cosmetic preservative diazolidinyl urea was studied in formaldehyde- and diazolidinyl urea-sensitized volunteer patients using a stepwise controlled exposure design. The test product was a facial moisturizer, preserved with varying concentrations of diazolidinyl urea, ranging from
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