1-Chloroethyl chloroformate is used as a selective dealkylating agent for tertiary amines.[1]
Application
1-Chloroethyl chloroformate was used:
for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection[2]
as catalyst in chemoselective desilylation of silyl-protected alcohols[1]
as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications[3]
as reagent to cleave benzhydryl groups from amines[4]
Methods for separation and determination of multiple drugs of abuse in biological fluids using capillary electrophoresis (CE) with native fluorescence and laser-induced fluorescence (LIF) detection are described herein. Using native fluorescence, normorphine, morphine, 6-acetyl morphine (6-AM), and codeine were analyzed
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