SML3687
TL8-506
≥98% (HPLC)
Synonym(s):
(1E,4E)-Ethyl 2-amino-8-(3-cyanophenyl)-3H-1-benzo[b]azepine-4-carboxylate, Ethyl 2-amino-8-(3-cyanophenyl)-3H-1-benzazepine-4-carboxylate, TL 8-506, TLR 8-506
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About This Item
Empirical Formula (Hill Notation):
C20H17N3O2
CAS Number:
Molecular Weight:
331.37
MDL number:
UNSPSC Code:
12352200
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
Motolimod (VTX-2337) analog and a toll-like receptor 8 (TLR8)-selective agonist with stronger activity than resiquimod (R848) and CL075 (3M002).
TL8-506 is a motolimod (VTX-2337) analog and a benzoazepine class toll-like receptor 8 (TLR8)-selective agonist. TL8-506 is commonly employed in the concentration range from 0.1 μg/mL to 1 μg/mL for stimulating cell surface TLR8 in cultures and is reported to be a stronger TLR8 ligand than the imidazoquinoline (IMDQ) derivatives (IQDs) resiquimod (R848) and CL075 (3M002).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Bin Tang et al.
Parasitology research, 119(8), 2505-2510 (2020-06-15)
Human trichinellosis is acquired by eating raw or undercooked meats carrying muscle larvae of Trichinella spp. Toll-like receptors (TLRs) are essential components of the innate immune system. However, little is known about the potential application of TLR agonists for immunotherapy
Jennifer Nelson et al.
Science advances, 6(26), eaaz6893-eaaz6893 (2020-07-09)
Messenger RNA (mRNA) represents an attractive therapeutic modality for potentially a wide range of clinical indications but requires uridine chemistry modification and/or tuning of the production process to prevent activation of cellular innate immune sensors and a concomitant reduction in
Thomas Ostendorf et al.
Immunity, 52(4), 591-605 (2020-04-16)
Human toll-like receptor 8 (TLR8) activation induces a potent T helper-1 (Th1) cell response critical for defense against intracellular pathogens, including protozoa. The receptor harbors two distinct binding sites, uridine and di- and/or trinucleotides, but the RNases upstream of TLR8
Jahnavi Aluri et al.
Blood, 137(18), 2450-2462 (2021-01-30)
Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the human immune response. We
Mahesh Chandra Patra et al.
Cells, 9(7) (2020-07-15)
Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a
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