Colony stimulating factor 1 receptor (CSF-1R) is encoded by the c-fms proto-oncogene mapped to human chromosome 5q33. The encoded protein acts as a receptor for CSF1 expressed in non-hematopoietic cells, such as macrophages, epithelial and fibroblasts cells and tumor cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human CSFR.
Immunogen Range: 531-580
Biochem/physiol Actions
Colony stimulating factor 1 receptor (CSF-1R)/ CSF-1 ligand system plays a vital role in the regulation of macrophage physiology in immune system.The encoded protein functions as a receptor and mediates the function of its ligand, colony stimulating factor 1, a cytokine involved in regulation of production, differentiation, and function of macrophages. Experimental analysis revealed that CSF-1/CSF-1R is overexpressed in patients with nasopharyngeal carcinoma when compared to patients with nasopharyngitis. Activated CSF-1R, is essential for monocyte differentiation to macrophages by oxidized low-density lipoprotein (Ox-LDL), which is a vital step in early atherogenesis. This protein is also associated with regulation of hematopoiesis. Deletion or mutation of this gene might be involved in the pathogenesis of myelodysplastic syndromes or of acute nonlymphocytic leukemia (ANLL).
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Overexpression of CSF-1R in nasopharyngeal carcinoma.
Huang L, et al.
Romanian Journal of Morphology and Embryology, 56(4), 1279-1283 (2015)
Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R).
Fuhrman B, et al.
Atherosclerosis, 196(2), 598-607 (2008)
Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders.
Le Beau MM, et al.
Science, 231(4741), 984-987 (1986)
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