Synthetic peptide directed towards the C terminal region of human ZIC2
Biochem/physiol Actions
ZIC2 is a C2H2-type zinc finger protein that functions as a repressor of transcription and regulates the tissue specific expression of dopamine receptor D1. Expression of ZIC2 is important for the development of nervous system and extension of neurites. ZIC2 inhibits the signaling mediated by Wnt/β-catenin during embryonic development.
Sequence
Synthetic peptide located within the following region: EPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGS
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 25(6), 538-541 (2013-02-19)
From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2(m1Nisw) mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the
International journal of cancer, 147(2), 505-518 (2020-02-18)
Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential
The Journal of biological chemistry, 286(43), 37732-37740 (2011-09-13)
The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription.
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