Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

61962

Sigma-Aldrich

Betaine

BioUltra, ≥99.0% (NT)

Synonym(s):

(Carboxymethyl)trimethylammonium inner salt, Oxyneurine, Trimethylglycine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(CH3)3N+CH2COO-
CAS Number:
107-43-7
Molecular Weight:
117.15
Beilstein:
3537113
EC Number:
203-490-6
MDL number:
MFCD00012123
UNSPSC Code:
41116107
PubChem Substance ID:
57651874
NACRES:
NA.25

product line

BioUltra

Quality Level

200

Assay

≥99.0% (NT)

impurities

insoluble matters, passes filter test

solubility

methanol: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤200 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤100 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

≤0.05 at 280 nm in methanol at 1 M
≤0.09 at 260 nm in methanol at 1 M

SMILES string

C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

InChI key

KWIUHFFTVRNATP-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

Betaine has been used in reverse transcription to increase the thermal stability of proteins and to destabilize the DNA helix.

Biochem/physiol Actions

Betaine has been shown to increase S-adenosylmethionine (SAM) levels and hence, may have a role in diminishing hepatic steatosis. It is an osmolyte which protects cells against environmental stress.
End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Full-length RNA-seq from single cells using Smart-seq2.
Picelli S
Nature Protocols, 9(1), 171-181 (2014)
Varsha Mathur et al.
Current biology : CB, 29(17), 2936-2941 (2019-08-20)
The apicomplexans are a group of obligate animal pathogens that include Plasmodium (malaria), Toxoplasma (toxoplasmosis), and Cryptosporidium (cryptosporidiosis) [1]. They are an extremely diverse and specious group but are nevertheless united by a distinctive suite of cytoskeletal and secretory structures related to
Shangli Cheng et al.
Cell reports, 26(10), 2593-2607 (2019-03-07)
Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency, accompanied by dynamic changes in X chromosome activity in females. To investigate the molecular attributes of this process, we performed single-cell RNA-seq analysis of 1,724 cells of
M F Abdelmalek et al.
The American journal of gastroenterology, 96(9), 2711-2717 (2001-09-25)
No effective therapy currently exists for patients with nonalcoholic steatohepatitis (NASH). Betaine, a naturally occurring metabolite of choline, has been shown to raise S-adenosylmethionine (SAM) levels that may in turn play a role in decreasing hepatic steatosis. Our aim was
M R Olthof et al.
Current drug metabolism, 6(1), 15-22 (2005-02-22)
High plasma concentrations of homocysteine may increase risk of cardiovascular disease. Folic acid lowers plasma homocysteine by 25% maximally, because 5-methyltetrahydrofolate is a methyl donor in the remethylation of homocysteine to methionine. Betaine (trimethylglycine) is also a methyl donor in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service