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Key Documents

Y0001392

Olanzapine impurity A

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile

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About This Item

Empirical Formula (Hill Notation):
C12H9N3O2S
CAS Number:
Molecular Weight:
259.28
Beilstein:
7485862
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

olanzapine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C12H9N3O2S/c1-8-6-9(7-13)12(18-8)14-10-4-2-3-5-11(10)15(16)17/h2-6,14H,1H3

InChI key

NPXUFPFFHANGDL-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Olanzapine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Environment

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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K Adrjanowicz et al.
The Journal of chemical physics, 136(23), 234509-234509 (2012-07-12)
The organic liquid ROY, i.e., 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, has been a subject of detailed study in the last few years. One interest in ROY lies in its polymorph-dependent fast crystal growth mode below and above the glass transition temperature. This growth mode
Christopher P Price et al.
Journal of the American Chemical Society, 127(15), 5512-5517 (2005-04-14)
The discovery and selective production of crystalline polymorphs, an outstanding problem in solid-state chemistry, is of great importance industrially in, for example, the manufacture of pharmaceuticals and pigments. Despite considerable efforts, no reliable method exists to produce all of the
C A Mitchell et al.
Journal of the American Chemical Society, 123(44), 10830-10839 (2001-11-01)
Crystallization of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (1), previously found to produce six conformational polymorphs from solution, on single-crystal pimelic acid (PA) substrates results in selective and oriented growth of the metastable "YN" (yellow needle) polymorph on the (101)(PA) faces of the substrate. Though
Ye Sun et al.
The Journal of chemical physics, 131(7), 074506-074506 (2009-08-28)
The liquid dynamics of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, named ROY for its red, orange, and yellow crystal polymorphs, was characterized by dielectric spectroscopy and differential scanning calorimetry. Four of these polymorphs show fast "diffusionless" crystal growth at low temperatures while three others do
Conformational and color polymorphism of 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophenecarbonitrile.
G A Stephenson et al.
Journal of pharmaceutical sciences, 84(11), 1385-1386 (1995-11-01)

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