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A7847

Sigma-Aldrich

Acridine Orange 10-nonyl bromide

≥90% purity (HPLC), powder or solid

Synonym(s):

10-Nonylacridine orange bromide, 3,6-Bis(dimethylamino)-10-nonylacridinium bromide

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About This Item

Empirical Formula (Hill Notation):
C26H38BrN3
CAS Number:
75168-11-5
Molecular Weight:
472.50
MDL number:
MFCD00467605
UNSPSC Code:
12171500
PubChem Substance ID:
329770942
NACRES:
NA.47
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Product Name

Acridine Orange 10-nonyl bromide,

Assay

≥90% (HPLC)

Quality Level

100

form

powder or solid

color

orange to red

mp

≥250 °C (lit.)

solubility

ethanol, DMSO: soluble

ε (extinction coefficient)

76-88 at 491-497 nm in methanol

fluorescence

λex 515-523  nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Br-].CCCCCCCCC[n+]1c2cc(ccc2cc3ccc(cc13)N(C)C)N(C)C

InChI

1S/C26H38N3.BrH/c1-6-7-8-9-10-11-12-17-29-25-19-23(27(2)3)15-13-21(25)18-22-14-16-24(28(4)5)20-26(22)29;/h13-16,18-20H,6-12,17H2,1-5H3;1H/q+1;/p-1

InChI key

DRBHTUDHPPBMCD-UHFFFAOYSA-M

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Related Categories

Application

Metachromatic dye useful as a mitochondrial probe in living cells. This dye has been used to analyze mitochondria by flow cytometry, characterize multidrug resistance, and measure changes in mitochondrial mass during apoptosis in rat thymocytes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV1413
MKCQ9655
MKCP9479
MKCN0658
MKCM7614

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Sonia Alcalá et al.
Nature communications, 11(1), 2682-2682 (2020-05-31)
Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSCs are extremely plastic and can successfully adapt to targeted therapies. In this study, we demonstrate
Monika Pichla et al.
Oxidative medicine and cellular longevity, 2020, 9260748-9260748 (2020-05-08)
Parkinson's disease (PD) patients can benefit from antioxidant supplementation, and new efficient antioxidants are needed. The aim of this study was to evaluate the protective effect of selected nitroxide-containing redox nanoparticles (NRNPs) in a cellular model of PD. Antioxidant properties
Roman Krestinin et al.
Biomedicines, 8(10) (2020-10-24)
Mitochondria are key organelles of the cell because their main function is the capture of energy-rich substrates from the cytoplasm and oxidative cleavage with the generation of carbon dioxide and water, processes that are coupled with the synthesis of ATP.
Carlos Sanchez-Martin et al.
Antioxidants & redox signaling, 34(7), 505-516 (2020-05-23)
Aims: TNF receptor-associated protein 1 (TRAP1), the mitochondrial paralog of the heat shock protein 90 (Hsp90) family of molecular chaperones, is required for neoplastic growth in several tumor cell models, where it inhibits succinate dehydrogenase (SDH) activity, thus favoring bioenergetic

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