This material has a molecular weight of 4514.2 Daltons and may be resuspended at 1 mg/mL in 1% NH4OH with sonication for 30 seconds to 1 minute. After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring the concentration to 1x.
AG968
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source
human
Quality Level
Assay
>97.0%
form
powder
manufacturer/tradename
Chemicon®
NCBI accession no.
UniProt accession no.
Gene Information
human ... APP(351)
General description
β Amyloid 1-42 is a derivative of integral membrane-bound amyloid precursor protein. It is the most important alloform of the Alzheimer′s peptide.
Application
β Amyloid 1-42, aβ, ultra-pure, HFIP, recombinant human has been used:
- to study its effect on the activity of mitochondrial BKCa (mitoBKCa) channels in human astrocytoma cells through patch-clamp technique
- to study its effect on alteration in protein levels of dystrophic neurites (DNs) forming proteins in mouse neuroblastoma cells
- to induce Alzheimer′s disease in a rat model for experimental studies
Biochem/physiol Actions
β Amyloid 1-42 causes neurotoxicity and is implicated in the pathogenesis of Alzheimer′s disease (AD). β Amyloid (βA) acts as a ligand for several receptors and other molecules involved in complex trafficking pathways in tissues and blood-brain barriers. βA along with amylin elevates cyclic adenosine monophosphate (cAMP) and Ca2+ in turn activates multiple signaling pathway mediators like mitogen-activated protein kinase (MAPK), protein kinase A/B, and cFOS. It acts as the main source of AD-associated neuroinflammation.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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