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Key Documents

05-502

Sigma-Aldrich

Anti-FRS2/SNT-1 Antibody

Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

monoclonal

species reactivity

rat, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FRS2(10818)

Specificity

FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells

Immunogen

Peptide corresponding to residues 283-297 of human FRS2/SNT-1

Application

Detect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
Developmental Signaling

Quality

routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody.

Target description

non-phosphorylated (68kDa) and phosphorylated (83kDa)

Physical form

0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
Format: Purified
Protein G Chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S O Meakin et al.
The Journal of biological chemistry, 274(14), 9861-9870 (1999-03-27)
We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated in response to nerve growth factor (NGF) stimulation. Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly
Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells.
Zhanbing Liu, Toshiyuki Ishiwata, Shaxia Zhou, Susanne Maier, Doris Henne-Bruns et al.
Pancreas null
Y R Hadari et al.
Molecular and cellular biology, 18(7), 3966-3973 (1998-06-25)
FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein (MAP) kinase signaling pathway. In this report, we demonstrate that FRS2 forms a complex
Agnes W Wong et al.
Journal of neurochemistry, 106(4), 1964-1976 (2008-07-16)
The neurotrophin receptor homolog (NRH2) is closely related to the p75 neurotrophin receptor (p75NTR); however, its function and role in neurotrophin signaling are unclear. NRH2 does not bind to nerve growth factor (NGF), however, is able to form a receptor
Vito Guagnano et al.
Cancer discovery, 2(12), 1118-1133 (2012-09-25)
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel

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