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Key Documents

888787D

Avanti

PAMPA Lipid Blend I

Avanti Research™ - A Croda Brand

Synonym(s):

PAMPA Lipid Blend I, DOPC:Stearic Acid (80:20, w/w) in Dodecane with 1% Ethanol for use in PAMPA assay, dodecane

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 3 mL (888787D-150mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

50 mg/mL (888787D-150mg)

application(s)

microbiology

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

General description

PAMPA Lipid Blend I is a lipid solution in dodecane/ethanol. Once opened, the contents of the glass ampoule should be transferred to a glass container with PTFE-lined screw cap closure for storage at -20°C. The transfer should be performed with a glass syringe or pipette. The solution should not contact plastic, i.e., do not transfer with plastic pipette tip or store in plastic vials.

Application

The PAMPA Lipid Blend I has been used in the parallel artificial membrane permeability assay (PAMPA) for the formation of artificial membrane.

Biochem/physiol Actions

The parallel artificial membrane permeability assay (PAMPA) is useful to study the oral absorption of drugs. It helps in specifying passive transcellular diffusion.

Packaging

5 mL Clear Glass Sealed Ampule (888787D-150mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H304

Precautionary Statements

P301 + P310 - P331 - P405 - P501

Hazard Classifications

Asp. Tox. 1

Supplementary Hazards

EUH066

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Li Di et al.
European journal of medicinal chemistry, 38(3), 223-232 (2003-04-02)
The recent advances in high throughput screening for biological activities and combinatorial chemistry have greatly expanded the number of drug candidates. Rapid screening for BBB penetration potential early in drug discovery programs provides important information for compound selection and guidance
High-throughput artificial membrane permeability studies in early lead discovery and development
Pharmacokinetic optimization in drug research (2001)
Fangzhou Xie et al.
Bioorganic chemistry, 92, 103273-103273 (2019-09-21)
Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of insulin signaling, is considered as a promising and validated therapeutic target for type 2 diabetes mellitus (T2DM) and obesity. Upon careful study, a series of 2-ethoxy-4-(methoxymethyl)benzamide and 2-ethoxy-5-(methoxymethyl)benzamide analogs designed
Fangzhou Xie et al.
European journal of medicinal chemistry, 164, 408-422 (2019-01-07)
Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In this work, a series of

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