1-(4-Pyridyl) piperazine (or 4-Piperazinopyridine) is an active structural component that is used as a building block to prepare various medicinally important active molecules.[1][2]
Application
1-(4-Pyridyl) piperazine can be used as a building block for the synthesis of:
Nocathiacin I analogs for antibacterial studies.[3]
4-amino-pyridyl derivatives, benzimido isoquinoline based derivatives and tert-pentylphenoxyalkyl piperazine derivatives for various biological applications.[4][5][6]
N ε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure?Activity Relationships, and Pharmacokinetic Profiling.
Wodtke R, et al.
Journal of Medicinal Chemistry, 61(10), 4528-4560 (2018)
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl) piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl) amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson D M, et al.
Journal of Medicinal Chemistry, 48(6), 1857-1872 (2005)
Benzimidazo [2, 1-a] benz [de] isoquinoline-7-one-12-carboxylic acid based fluorescent sensors for pH and Fe3+
Zhao Y, et al.
Journal of Photochemistry and Photobiology A: Chemistry, 314(12), 52-59 (2016)
Synthesis, characterization, and bioactivity of new bisamidrazone derivatives as possible anticancer agents.
Polymethacrylates containing a 4-amino-pyridyl derivative covalently attached as effective catalysts in acylation chemistry: self-activation by neighboring group effects
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