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Z4250

Sigma-Aldrich

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

Sinónimos:

Yeast Cell Wall

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About This Item

Número de CAS:
58856-93-2
Número MDL:
MFCD00082157
Código UNSPSC:
12352202
NACRES:
NA.61
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

Saccharomyces cerevisiae

Nivel de calidad

200

Formulario

powder with small lumps

técnicas

flow cytometry: suitable
tissue culture: suitable

color

off-white to light brown

temp. de almacenamiento

2-8°C

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Categorías relacionadas

Aplicación

  • in flow cytometry[1]
  • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)[2]

Zymosan A from Saccharomyces cerevisiae has been used:
  • as a positive control to determine the activation of complement cascade[3]
  • for respiratory burst (RB) assay[4]
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)[5]
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium[6]
  • to induce thermal hyperalgesia in mice[7]

Acciones bioquímicas o fisiológicas

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.[8]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCM7622
BCCL0988
BCCJ4416
BCCG7848
BCCF4922

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Maria M M Kaisar et al.
PLoS biology, 16(4), e2005504-e2005504 (2018-04-19)
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive
Self-mineralizing Ca-enriched Methacrylated Gellan Gum Beads for Bone Tissue Engineering
VieiraS, et al.
Acta Biomaterialia (2019)
ACUTE INFLAMMATION AND RECOVERY IN RATS AFTER INTRATRACHEAL INSTILLATION OF A 1?3-
Young SH, et al.
Journal of Toxicology and Environmental Health. Part A, 64(4), 311-325 (2001)
PAMP induced expression of immune relevant genes in head kidney leukocytes of rainbow trout (Oncorhynchus mykiss)
Chettri JK, et al.
Developmental and Comparative Immunology, 35(4), 476-482 (2011)
The role of properdin in zymosan-and Escherichia coli-induced complement activation
Harboe M, et al.
Journal of immunology (Baltimore, Md. : 1950), 1200269-1200269 (2012)
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Questions

1–9 of 9 Questions  

  1. How can I solubilize Zymosan? The information sheet does not provide this information. Can it be dissolved in water?

    1 answer

    1. This product is soluble in organic solvents as follows:
      - Chloroform: 100 µg/ml
      - Dimethyl sulfoxide: 200 µg/ml
      - Ethanol: 100 µg/ml.

      According to the 'Solubility/Solution Stability' section in the product information sheet, this product is not soluble in water but can be suspended uniformly in saline solution.

      Helpful?

  2. Is Z4250, Zymosan A from Saccharomyces cerevisiae, soluble in DMSO?

    1 answer

    1. Yes, this item is soluble in the following solvents:
      - Chloroform: 100 µg/ml
      - DMSO: 200 µg/ml
      - Ethanol: 100 µg/ml

      Helpful?

  3. Can Product Z4250, Zymosan suspension be autoclaved?

    1 answer

    1. We have no information as to whether zymosan suspensions can be autoclaved.  However, suspensions are stable to boiling conditions.

      Helpful?

  4. How can Product Z4250, Zymosan be prepared for use in a properdin assay?

    1 answer

    1. Information on preparation of zymosan for use in a properdin assay, which includes boiling zymosan suspensions, is described on the product information sheet (under Documents, above).

      Helpful?

  5. How can I solubilize Zymosan, Product Z4250?

    1 answer

    1. Solubility information can be found in the product information sheet (under Documents, above) on our website.

      Helpful?

  6. What is the particle size of Product Z4250, Zymosan?

    1 answer

    1. Sigma-Aldrich does not measure the particle size of zymosan. The average diameter of zymosan particles has been reported to be about 3 μm, as described on the product information sheet (under Documents, above), with the cited reference.

      Helpful?

  7. What is the source of the Zymosan in Product Z4250?

    1 answer

    1. This zymosan is prepared from single cell yeast.

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  8. What is the appearance of Product Z4250, Zymosan?

    1 answer

    1. The product is a powder which is described on the specification sheet.

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  9. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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