V4253

[β-Mercapto-β,β-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin

≥97% (HPLC)

• Fórmula empírica (notación de Hill): C₅₃H₇₅N₁₃O₁₁S₂
• Número CAS: 77453-01-1
• Peso molecular: 1134.37
• NACRES: NA.32
• PubChem Substance ID: 329829049
• UNSPSC Code: 51111800
• MDL number: MFCD00076752
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥97% (HPLC)

Propiedades

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• solubility: water: 1 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC2=O)C(C)C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1
• InChI: 1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,44-/m0/s1
• InChI key: SDFJYGJKEXYVCG-ZZTMPEIHSA-N
• Gene Information: human ... AVPR1A(552), AVPR2(554), OXT(5020), OXTR(5021) ; mouse ... AVPR1A(54140), AVPR2(12000) ; rat ... AVPR1A(25107), AVPR2(25108), OXT(18429), OXTR(18430)

Descripción

Application

[Beta-Mercapto-beta, beta-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin is a potent V1a and V2 vasopressin receptor anatgonist, used for examining the impact of vasopressin V1receptor blockade in rats.The product was also be used for visualizing cell surface V1a receptors in rat hepatocytes by using high-affinity fluorescent linear antagonist, Rhm8 -PVA.

Biochem/physiol Actions

Vasopressin also known as antidiuretic hormone (ADH) or argipressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.ADH can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H332
• pcodes: P261 - P271 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves