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V3501

Sigma-Aldrich

Vitamin K1

viscous liquid

Sinónimos:

2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)

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About This Item

Fórmula empírica (notación de Hill):
C31H46O2
Número de CAS:
84-80-0
Peso molecular:
450.70
Beilstein:
2568816
Número CE:
201-564-2
Número MDL:
MFCD00214063
Código UNSPSC:
12352205
eCl@ss:
34058015
ID de la sustancia en PubChem:
24900741
NACRES:
NA.28
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

synthetic (organic
inorganic)

Nivel de calidad

100

Formulario

viscous liquid

color

, Yellow to Very Dark Yellow to Very Dark Orange

índice de refracción

n20/D 1.527 (lit.)

mp

−20 °C (lit.)

densidad

0.984 g/mL at 25 °C (lit.)

temp. de almacenamiento

2-8°C

cadena SMILES

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

Clave InChI

MBWXNTAXLNYFJB-NKFFZRIASA-N

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Categorías relacionadas

Descripción general

Vitamin K1/Phylloquinone is a prenylated naphthoquinone. It is produced by plants, green algae and some species of cyanobacteria.[1]

Aplicación

Vitamin K1 has been used in the preparation of culture media.[2]

Acciones bioquímicas o fisiológicas

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor. Vitamin K1 is essential for blood coagulation, bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil is the most important dietary source of vitamin K for humans.[1]

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCM3613
BCCL7693
BCCK3926
MKCG2073
BCCH6670

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Bacteroides disiens sp. nov. and Bacteroides bivius sp. nov. from human clinical infections
Holdeman L V and Johnson J L
International Journal of Systematic and Evolutionary Microbiology (1977)
Phylloquinone (vitamin K1): occurrence, biosynthesis and functions
Basset J G, et al.
Mini-Reviews in Medicinal Chemistry (2017)
Ellen M Apalset et al.
Bone, 49(5), 990-995 (2011-08-16)
Evidence of the effect of vitamin K on bone health is conflicting. The aim was to investigate the association between intake of vitamins K1 and K2 and subsequent risk of hip fracture in a general population sample, as well as
Edward P A Gebuis et al.
Haematologica, 96(4), 583-589 (2011-01-05)
Poor anticoagulant stability in patients using vitamin K antagonists is a risk factor for both bleeding and thrombosis. In previous studies supplementation with low dose vitamin K(1) was shown to improve the stability of anticoagulant control. We set up a
Beverly Murray et al.
The Journal of antimicrobial chemotherapy, 75(8), 2149-2155 (2020-04-15)
Ibezapolstat (ACX-362E) is the first DNA polymerase IIIC inhibitor undergoing clinical development for the oral treatment of Clostridioides difficile infection (CDI). In this study, the in vitro activity of ibezapolstat was evaluated against a panel of 104 isolates of C.
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How much of Vitamin K1 per litre of anaerobic gut-mimicking media is recommended?

    1 answer

    1. This is not an application that is QC tested, but the literature indicates that a good starting point might be 0.5 ug/mL. Please see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658209/

      Another option would be to use a Vitamin K1 ready-made solution, such as: https://www.sigmaaldrich.com/product/sigma/sbr00053

      This product is at a concentration of 5 mg/mL, but recommends dilution down to 1 ug/mL prior to use, and states that the optimal concentration may vary by strain so, further experimentation may be necessary to determine optimal conditions.

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