T6700

TRAM-34

≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid

• Sinónimos: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
• Fórmula empírica (notación de Hill): C₂₂H₁₇ClN₂
• Número CAS: 289905-88-0
• Peso molecular: 344.84
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826852
• NACRES: NA.77
• MDL number: MFCD09842562
• Assay: ≥98% (HPLC)
• Form: solid

Propiedades

• Nombre del producto: TRAM-34, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: 2 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
• InChI: 1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
• InChI key: KBFUQFVFYYBHBT-UHFFFAOYSA-N

Descripción

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H413
• pcodes: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves