SML3909

SGC-CK2-2

≥98% (HPLC)

• Sinónimos: 5-(Benzylamino)pyrimido[4,5-c]quinoline-8-carboxylic acid
• Fórmula empírica (notación de Hill): C₁₉H₁₄N₄O₂
• Número CAS: 2825012-70-0
• Peso molecular: 330.34
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD35067914
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Descripción

Biochem/physiol Actions

Highly potent and selective casein kinase 2 (CK2, CKII) inhibitor that inhibits downstream AKT S129 phosphorylation in MDA-MB-231 cells

SGC-CK2-2 is a highly potent and selective casein kinase 2 (CK2, CKII) inhibitor (IC50 = 3 nM/CK2α and <1 nM/CK2α by enzyme assay; CK2α/CK2α′ IC50 = 920/200 nM by cellular NanoBRET; genomewide by DiscoverX scanMAX panel at 1 μM). SGC-CK2-2 effectively inhibits CK2 downstream signaling in MDA-MB-231 cells (AKT pS129 IC50 ~5 μM post 24h) without cytotoxicity (up to 10 μM & 48h).

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable