SML3817

TLR2-IN-C29

≥98% (HPLC)

• Sinónimos: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methylbenzoic acid, C29
• Fórmula empírica (notación de Hill): C₁₆H₁₅NO₄
• Número de CAS: 363600-92-4
• Peso molecular: 285.29
• Código UNSPSC: 51111800
• Código UNSPSC: 12352200
• NACRES: NA.21

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: yellow to orange
• solubilidad: DMSO: 2 mg/mL, clear
• temp. de almacenamiento: -10 to -25°C
• cadena SMILES: O=C(C1=C(C)C(N=CC2=C(O)C(OC)=CC=C2)=CC=C1)O
• InChI: 1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,18H,1-2H3,(H,19,20)
• Clave InChI: WTGMGRFVBFDHGQ-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Selective TIR domain-targeting toll-like receptor 2 (TLR2) antagonist that inhibits human TLR2/1- & TLR2/6-, murine TLR2/1-, but not murine TLR2/6-mediated signaling.

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist that inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable